Massachusetts Institute of TechnologyCambridge, MA
Collaborated in a project to identify the role of astrocytes in neuron coding and motor learning.
Performed analysis for neuronal encoding of forearm motion.
- Built a lever push behavioral task rig and integrated it with 2p microscopy.
- Decoded motion trajectory from neuronal activity with support vector regression, GRU-RNN and particle filtering; evaluated with a continuous estimate of mutual information based on k-nearest neighbors.
- Built a GLM encoding model of behavior features in neuronal activity; found that astrocyte-manipulation wiped out neuron encoding of task delay.
Led a project in neuron ensemble formation in M1 during motor learning and transfer learning, by chronically tracking same neurons with 2p Ca2+ imaging.
Developed a motorized lever push rig to apply force field or change movement gain.
- Led an investigation in the effect of inhibition reduction in Rett Syndrome on both neuron coding and behavioral phenotypes, as well as their rescue. Adapted and validated a chloride imaging method to use with in vivo 2p imaging.
- Led a team to collaborate in a larger translational project that created drug screening platform and screened drugs targeting a chloride transporter (KCC2) to treat Rett Syndrome. Directed research assistants and students to perform pre-clinical physiological and behavioral tests. Performed statistical analysis on the whole project, using mixed linear models and two-way aligned rank ANOVA.
- Created and optimized automatic system for two-photon imaging data processing pipeline, including aligning, ROI extraction, and Ca2+ trace deconvolution.
MIT class: IAP 2017 Introduction to neuron population recording methods
Gave introductory lectures on neuron recording methods including electrode, optical imaging, and two photon imaging methods.
Vanderbilt University class: BSCI 258 Vertebrate Physiology
Guest lecturer (invited by Dr. Clint Carter)
Gave lectures on central nervous system, wrote and graded related test questions.